MPAA Rating: PG

Part animated, part live-action adventure about a maverick white blood cell (voiced by Chris Rock) that's on a mission to track down and fend off a deadly blood virus threatening its human host (Bill Murray). The blood cell's partner is a no-nonsense cold tablet (David Hyde Pierce). Also with Molly Shannon, Elena Franklin, Chris Elliott, Laurence Fishburne, Brandy Norwood and William Shatner. Directed by Bobby & Peter Farrelly. [1:38]

SEX/NUDITY 2 - Two animated characters kiss romantically a few times. We see a billboard with a huge picture of buttocks. We see a photo of an animated character's very large wife in a tiny bikini. An animated character is seen looking at a "DNA Monthly" magazine as if it is a Playboy-like magazine with a centerfold, and he makes suggestive remarks. A male animated character flirts with a female animated character and makes suggestive remarks. We see a man in his underwear (he has forgotten his pants). We see a night club with animated characters dancing and gyrating; one character has three breasts. We see a man's large tummy hang out of his shirt.

VIOLENCE/GORE 5 - There is a lot of bodily humor and slimy gross-out stuff throughout the film, both inside a man's body (the characters are animated) and outside (it is live-action): A man opens his mouth that is full of half-chewed food, some mucus runs out of a man's nose and he sucks it back in with a big sniff, a man vomits all over the front of a woman's dress, and we see the vomit scene in photos also. A man talks about his ingrown toenail and puts his bloody swollen foot on the table at a restaurant, and a man has a huge pimple on his forehead that throbs and bursts and the pus lands on a woman's lip. A man stands over a sink apparently after having vomited, and a man eats a hard boiled egg which had fallen on the floor, right out of a monkey's cage -- we follow the egg through the man's mouth; a huge, bubbling mass of slime covers the egg and explodes splattering animated characters with drippy goo. "Nose-juice" cannons are fired at dust particles, and a membrane cracks and releases a flood of mucus causing two animated characters to float down mucus rapids. There are references to the odor of the bowels, and we see a "pus cookies" stand. A monkey and a man both scratch their buttocks. We hear sounds of flatulence and hear a man urinating -- while we're also watching his bladder emptying. We see a man in an emergency room and he dies after his temperature climbs to 108°, and a man passes out behind the wheel of a car and we see him being taken away by an ambulance. We see a scary looking virus: he is big and red and has glowing yellow eyes and really long spiky finger nails that he uses to infect parts of the body; everything he touches catches on fire. He is referred to as the "Red Death" and "Thrax." There's a helicopter chase between animated characters that are white blood cells (they are the police) and germs (the criminals) through a man's body; there's another chase between police and a germ that causes the police to be sprayed with green goo and their cars to overturn. We see an animated character disintegrate; his face crumbles and his eye pops out. A couple of animated characters are slashed by a germ and we see their pieces floating in some goo; the germ slashes another animated character who splatters, and two other animated characters are killed. Animated characters panic and run around in a frenzy. Two animated characters yell at each other and grab each other around the throat. Two animated characters have a fistfight and the one chokes the other. Two animated characters dangle from a man's eyelash and then struggle with each other; one falls into a beaker of alcohol and melts. An animated character falls to the ground and is trapped under something that looks like muscle fibers. An animated character jumps from a helicopter and crashes onto a car which then crashes into a billboard. An animated character that's a germ causes sirens to ring and a man's temperature starts climbing. The germ slashes cars and burns up a road. An animated character is sucked into a germ extermination container, an animated character jumps on another character's head and screams in fear. A germ is shot and its hand freezes. Two animated characters fight and wrestle, and an animated character is held by a couple of animated characters and threatened. An animated character throws a grenade which explodes and covers everything with cold remedy medication. We see a couple of animated characters cleaning up in a man's stomach (presumably) and they are surrounded by slimy, drippy goo. There are a few scenes with characters yelling at and insulting each other. The opening credits scene has amoebae-like creatures swimming around. A man falls down complaining of a painful cramp in his leg. A man wrestles with and head-butts a monkey. Some reckless driving.

PROFANITY 2 - There are several euphemistic mispronunciations or rephrasings of common obscene or profane exclamations (e.g. "holy spit"). There are also a few anatomical terms, a few sexual references, and some insults and religious exclamations. [profanity glossary]

DISCUSSION TOPICS - The death of a parent, self-destructive behavior, buying votes, the conscience, the subconscious, grief, fitting in.

MESSAGE - Take care of your body.

(Note: There is an emotionally painful scene where we see a young girl sobbing uncontrollably over her father as he dies.)

Special Keywords: S2 - V5 - P2 - MPAAPG